The inhalation route is the only current way of consuming both substances jointly, involving risks and damages inherent to the alveolar route and the high-speed of absorption of this route. Nicotine is the psychoactive compound present in the tobacco plant, responsible for creating addiction. Tetrahydrocannabinol is the cannabinoid compound with the greatest psychoactive capacity and the one that contributes most to the addictiveness of cannabis.
Both nicotine and tetrahydrocannabinol produce complex pharmacological effects on the central nervous system, cardiovascular system, respiratory system, etc. Tobacco addiction is possibly the most common unwanted effect affecting cannabis users.
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