ISSN: 2695-2785

Volume 1, No 2 (), pp. -

Doi: en trámites

Luis Torres Pérez, Mónica Rodríguez Bouza, Ana María Leal Valle, Jesús Bujalance Hoyos and Cipriano Viñas Vera

Manejo de los Vómitos: Interrelación entre la Edad, el Modo de Presentación y la Sintomatología

Abstract: AbstractThe present article addresses vomiting in paediatric emergencies, focusing on aetiology. The signs and symptoms, as well as the age of the child are assessed and linked to the probable causal factors of this clinical feature in order to guide the therapeutic intervention. Clinical studies and current systematic reviews have been consulted for the preparation of this article.

Keywords: Vomiting; Child guidance

VÓMITOS

Vomiting is a very common symptom in children. Determining its relationship with potentially dangerous conditions, as well as its diagnosis and treatment depends on both the age of the child and the mode of presentation of this symptom.

The assessment of the impact of this clinical feature on the child’s general state (lack of energy, drowsiness, pallor) and hydroelectrolytic metabolism is decisive. The child usually presents in a stable situation and we are able to conduct a case history and initial examination focusing on the following:

  • Presence of fever

  • Digestive symptoms and intestinal pattern: nausea, vomiting, and presence of diarrhoea.

  • Activity pattern: appetite, sleep, play, and reactivity.

  • Presence of thirst and signs of dehydration: decreased skin turgor, sunken fontanelles.

  • Respiratory pattern: frequency and depth of breathing (pH alteration). (Shields & Lightdale, 2018)

(Figure 1. Interrelation between age, mode of presentation, and symptoms)

Figure 1. Interrelation between age, mode of presentation, and symptoms

image1-1-1-2151-1-11-20191031.png

Source: Shields & Lightdale, 2018

AETIOLOGICAL APPROACH

The etiology of vomiting (and nausea) to facilitate a price and rapid approach based on the variables shown in Table 1. Pattern by age

Table 1. Pattern by age

*UTI: urinary tract infection / ICP: intracranial pressure / AGE: acute gastroenteritis / GERD: gastroesophageal reflux disease / THC: tetrahydrocannabinol.

PATTERN 0-1 month(s) 1-12 month(s) 1-4 year(s) 5-11 years 12-14+ years
ACUTE Food intolerancel Foreign body Foreign body Appendicitis Choledocholithiasis
Hirschprung disease Food intolerance Laryngitis Diabetic ketoacidosis Diabetic ketoacidosis
Drug poisoning Drug poisoning Drug poisoning Drug poisoning Drug poisoning
Sepsis Increased ICP Toxic ingestion Pancreatitis
Meningitis Otitis media Otitis media Otitis media
Pyloric stenosis UTI. Kidney disease Constipation
Bile duct alteration Intussusception UTI
Intestinal atresia AGE AGE
Toxic ingestion
Bile duct alteration
Pancreatitis
Rumiation
CHRONIC Adrenal insufficiency GERD Coeliac disease Coeliac disease Bezoar
GERD Eosinophilic oesophagitis Eosinophilic oesophagitis Pregnancy
Hirschprung disease Gastritis (con o sin H. pylori) Drug addiction (THC)
Bile duct alteration Gastroparesis
Intestinal atresia Peptic ulcer disease
CYCLIC Adrenal insufficiency Adrenal insufficiency Adrenal insufficiency Cyclic vomiting syndrome Abdominal migraine
Inborn errors of metabolism Intussusception Constipation Urinary obstruction Drug use (THC)
Malrotation with volvulus Malrotation with volvulus Cyclic vomiting syndrome
Eating disorder
Superior mesenteric artery syndrome

Source: Di Lorenzo C. Approach to the infant or child with nausea and vomiting Up to Date 2019 y Shields & Lightdale, 2018.

It should be noted that the presence of enamel lesions may be an early sign of eating disorders (e.g. anorexia, bulimia) even in children (Uhlen, Tveit, Refsholt Stenhagen, & Mulic, 2014)

CLINICAL GUIDANCE BASED ON THE RESULTS OF THE CASE HISTORY AND EXAMINATION

The first thing to do is to find out if we are dealing with a healthy child or if he or she has any illnesses. The epidemiological environment (e.g. AGE, food poisoning) must be investigated, and any history of head or abdominal trauma (duodenal haematoma) must be taken into account. Toxic ingestion is more likely in children aged 1-5 years and adolescents who present with vomiting accompanied by changes in their level of consciousness, ataxia, and multiorgan or “strange” syndromes; even more so if there is a history of pica, or accidental or intended ingestion. Polyhydramnios is a common previous condition in neonates with congenital bowel obstruction (Shields & Lightdale, 2018) , See Table 2. Clinical guidance 1

Table 2. Clinical guidance 1

SYMPTOMS CLINICAL GUIDANCE
HISTORY
History of vomiting or diarrhoea in people surrounding the child AGE
Sudden onset of symptoms (nausea, vomiting, diarrhoea)
  • Viral gastroenteritis

  • Infectious diseases (sepsis, enteritis/colitis, appendicitis)

  • Hirschprung disease associated with enterocolitis

Vomiting in the morning
  • Pregnancy

  • Increased ICP

  • Cyclic vomiting syndrome

Vomiting without nausea (spontaneous vomiting) Increased ICP
Bilious emesis Bilious emesis requires an immediate assessment to relieve an intestinal obstruction distal to the angle of Treitz. Non-bilious vomiting is less frequently associated with an obstruction of the gastrointestinal tract. If faeces is detected, a distal obstruction is very likely to be the case (large intestine).
Haematemesis The blood usually comes from the upper respiratory tract. Sometimes haematemesis is due to Mallory-Weiss syndrome, gastritis caused by anti-inflammatory drugs, etc.
Effortless vomiting
  • Reflux

  • Rumiation

Periodic episodes of vomiting
  • Cyclic vomiting syndrome

  • Metabolic conditions, including porphyriaa

  • Migraine (family history)

  • Oncological conditions

  • Family dysfunction

Vomiting associated with food ingestion
Vomiting within a few minutes and up to 2 hours after eating, usually accompanied by skin rashes or respiratory symptoms Food allergy
Subacute clinical features with diarrhoea Bowel disease due to food intolerance
After introducing lactose Galactosemia
After introducing fructose/sucrose Hereditary fructose intolerance
Indigestion with vomitings Achalasia

Source: Shields & Lightdale, 2018

Vomiting is nonspecific in childhood and may be caused by a variety of conditions. Once we have evaluated the degree to which the general state of health has been affected, the priority is to rule out the most serious causes of vomiting in children: surgical abdomen, severe non-surgical abdominal conditions, intracranial infection, intracranial hypertension, sepsis, and severe metabolic disorders (Hyams et al., 2016) , See Table 3. Clinical guidance 2.

Table 3. Clinical guidance 2

EXAMINATION CLINICAL GUIDANCE
HISTORY
Marked abdominal distension, visible intestinal loops, bilious emesis, absence of bowel movements or borborygmi, flatulence, foul-smelling stools Bowel obstruction
Hepatosplenomegaly, jaundice
  • Hepatitis

  • Viral infection (e.g. mononucleosis)

  • Metabolic disorders

  • Epigastrium: pancreatitis, peptic ulcer disease, gastritis

Ataxia, dizziness, nystagmus Vestibular condition or acute cerebellar ataxia
Papilloedema Increased ICP
Ambiguous genitalia Congenital adrenal hyperplasia or adrenal insufficiency
Strange smell (bad breath) Metabolic problem
Parotid inflammation Bulimia

Source: Hyams et al., 2016

USEFULNESS OF SOME LABORATORY TESTS

The evidence indicates some tests that are easy to interpret and do not require complex resources, which can guide the diagnostic-therapeutic approach, and which are included in the following table. Table 4. Usefulness of laboratory tests

Table 4. Usefulness of laboratory tests

TEST CLINICAL GUIDANCE
Blood count
  • Anaemia and iron deficiency associated with inflammatory bowel disease, peptic ulcer disease, and gastritis.

  • Leukocytosis is related to bacterial infections.

Electrolytes, Urea/creatinine
  • Electrolyte alterations are associated with pyloric stenosis, metabolic alterations, and adrenal insufficiency.

  • Elevated levels of urea and creatinine point to kidney disorders.

Hepatic function
  • Evaluation of transaminases points to gallbladder conditions.

Ketone bodies
  • Metabolic disorders: diabetes, galactosaemia..

  • Prolonged fasting.

Source: Shields & Lightdale, 2018

THERAPEUTIC APPROACH

Beyond the aetiological approach, which is of paramount importance, symptom management often focuses on treatment in the community care setting.

Without evidence of severity, improvement in clinical features is achieved by allowing the bowel to rest and maintaining an adequate level of hydration. The basic pillars of the management of AGE are oral rehydration and early feeding. In the case of infants, early feeding should be maintained and, in the rest of children, the intake of hydroelectrolytes should be ensured in accordance with the losses and without forcing early feeding (Shields & Lightdale, 2018)

Together with this, the use of antiemetic medication encourages the positive progression of the most acute symptoms. There are numerous drugs and therapeutic regimens depending on age, the characteristics of the drug, and the clinical features being addressed (Hyams et al., 2016), (Phillips et al., 2010) ,.

Table 5. Most frequently used medications , summarises the most frequently used medications with the greatest evidence for safe use in clinical settings, including their complications or recommendations for the paediatric setting (Frelich et al., 2018), (Tomasik, Ziółkowska, Kołodziej, & Szajewska, 2016)

Table 5. Most frequently used medication

MEDICATION DOSE GROUP / RECEPTOR NOTES
Ondansentron 0.3-0.4 mg/kg per dose every 4-6 h Serotonin antagonist / 5-HT3 May cause diarrhoea
Granisetron 40 μg/kg/dose every 12 h Serotonin antagonist / 5-HT3
Ginger 250 mg every 8 h Serotonin antagonist The mechanism of action of ginger is not completely understood
Amitriptyline 0.25 mg/kg per day (max. 1 mg/kg per day) Antidepressant / Serotonin Increased risk of cardiac arrhythmia
Erythromycin 0.5 mg/kg per dose every 6 h Prokinetic Can increase risk of pyloric stenosis in infants
Cyproheptadine 0.25-0.5 mg/kg per day Antihistamine / H1 Stimulates appetite
Diphenhydramine 5 mg/kg per day (divided into 3-4 doses) Antihistamine / H1, D2
Promethazine 5-10 mg/kg every 4-6 h (≥ 40 kg) Dopamine antagonist / D2 Contraindicated in children < 2 y old due to respiratory depression
Metoclopramide 0.1-0.2 mg/kg per dose every 4-6 h Dopamine antagonist / D2 Increased risk of tardive dyskinesia (extrapyramidal condition)
Aprepitant

Children 6-30 kg: 3 mg/kg on day 1, then 2 mg/kg on days 2 and 3.

Children >30Kg: 125 mg on day 1, then 80 mg on days 2 and 3.

Neurokinin (central) / NK1 Indicated for chemotherapy-induced nausea. Causes fatigue, dizziness. Not for long-term use

Source: Shields & Lightdale, 2018

Acknowledgment

This publication has been possible to the cooperation program Interreg VA España-Portugal POCTEP - RISCAR 2014-2020.

http://www.poctep.eu

RINSAD

The Journal of Childhood and Health (Revista Infancia y Salud - RINSAD), ISSN: 2695-2785, arises from the collaboration between the administrations of Portugal, Galicia, Castilla y León, Extremadura, and Andalusia, within the Interreg Spain-Portugal RISCAR project, and aims to disseminate scientific articles on children’s health, providing researchers and professionals with a scientific base from which to learn about the latest advances in their respective fields.

The RISCAR project is co-financed by the European Regional Development Fund (ERDF) through the Interreg Program V-A Spain-Portugal (POCTEP) 2014-2020, with a total budget of € 649.699.

RINSAD is the result of the Interreg Spain - Portugal RISCAR project in collaboration with the University of Cádiz and the Nursing and Physiotherapy Department of the University of Cádiz , Cádiz, Spain.

The works published in this journal are licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International license.

References