Abstract: AbstractThe present article addresses vomiting in paediatric emergencies, focusing on aetiology. The signs and symptoms, as well as the age of the child are assessed and linked to the probable causal factors of this clinical feature in order to guide the therapeutic intervention. Clinical studies and current systematic reviews have been consulted for the preparation of this article.
Keywords: Vomiting; Child guidance
Vomiting is a very common symptom in children. Determining its relationship with potentially dangerous conditions, as well as its diagnosis and treatment depends on both the age of the child and the mode of presentation of this symptom.
The assessment of the impact of this clinical feature on the child’s general state (lack of energy, drowsiness, pallor) and hydroelectrolytic metabolism is decisive. The child usually presents in a stable situation and we are able to conduct a case history and initial examination focusing on the following:
Presence of fever
Digestive symptoms and intestinal pattern: nausea, vomiting, and presence of diarrhoea.
Activity pattern: appetite, sleep, play, and reactivity.
Presence of thirst and signs of dehydration: decreased skin turgor, sunken fontanelles.
Respiratory pattern: frequency and depth of breathing (pH alteration). (Shields & Lightdale, 2018)
(Figure 1. Interrelation between age, mode of presentation, and symptoms)
The etiology of vomiting (and nausea) to facilitate a price and rapid approach based on the variables shown in Table 1. Pattern by age
PATTERN | 0-1 month(s) | 1-12 month(s) | 1-4 year(s) | 5-11 years | 12-14+ years |
---|---|---|---|---|---|
ACUTE | Food intolerancel | Foreign body | Foreign body | Appendicitis | Choledocholithiasis |
Hirschprung disease | Food intolerance | Laryngitis | Diabetic ketoacidosis | Diabetic ketoacidosis | |
Drug poisoning | Drug poisoning | Drug poisoning | Drug poisoning | Drug poisoning | |
Sepsis | Increased ICP | Toxic ingestion | Pancreatitis | ||
Meningitis | Otitis media | Otitis media | Otitis media | ||
Pyloric stenosis | UTI. Kidney disease | Constipation | |||
Bile duct alteration | Intussusception | UTI | |||
Intestinal atresia | AGE | AGE | |||
Toxic ingestion | |||||
Bile duct alteration | |||||
Pancreatitis | |||||
Rumiation | |||||
CHRONIC | Adrenal insufficiency | GERD | Coeliac disease | Coeliac disease | Bezoar |
GERD | Eosinophilic oesophagitis | Eosinophilic oesophagitis | Pregnancy | ||
Hirschprung disease | Gastritis (con o sin H. pylori) | Drug addiction (THC) | |||
Bile duct alteration | Gastroparesis | ||||
Intestinal atresia | Peptic ulcer disease | ||||
CYCLIC | Adrenal insufficiency | Adrenal insufficiency | Adrenal insufficiency | Cyclic vomiting syndrome | Abdominal migraine |
Inborn errors of metabolism | Intussusception | Constipation | Urinary obstruction | Drug use (THC) | |
Malrotation with volvulus | Malrotation with volvulus | Cyclic vomiting syndrome | |||
Eating disorder | |||||
Superior mesenteric artery syndrome |
Source: Di Lorenzo C. Approach to the infant or child with nausea and vomiting Up to Date 2019 y Shields & Lightdale, 2018.
It should be noted that the presence of enamel lesions may be an early sign of eating disorders (e.g. anorexia, bulimia) even in children (Uhlen, Tveit, Refsholt Stenhagen, & Mulic, 2014)
The first thing to do is to find out if we are dealing with a healthy child or if he or she has any illnesses. The epidemiological environment (e.g. AGE, food poisoning) must be investigated, and any history of head or abdominal trauma (duodenal haematoma) must be taken into account. Toxic ingestion is more likely in children aged 1-5 years and adolescents who present with vomiting accompanied by changes in their level of consciousness, ataxia, and multiorgan or “strange” syndromes; even more so if there is a history of pica, or accidental or intended ingestion. Polyhydramnios is a common previous condition in neonates with congenital bowel obstruction (Shields & Lightdale, 2018) , See Table 2. Clinical guidance 1
SYMPTOMS | CLINICAL GUIDANCE |
---|---|
HISTORY | |
History of vomiting or diarrhoea in people surrounding the child | AGE |
Sudden onset of symptoms (nausea, vomiting, diarrhoea) | |
Vomiting in the morning | |
Vomiting without nausea (spontaneous vomiting) | Increased ICP |
Bilious emesis | Bilious emesis requires an immediate assessment to relieve an intestinal obstruction distal to the angle of Treitz. Non-bilious vomiting is less frequently associated with an obstruction of the gastrointestinal tract. If faeces is detected, a distal obstruction is very likely to be the case (large intestine). |
Haematemesis | The blood usually comes from the upper respiratory tract. Sometimes haematemesis is due to Mallory-Weiss syndrome, gastritis caused by anti-inflammatory drugs, etc. |
Effortless vomiting | |
Periodic episodes of vomiting | |
Vomiting associated with food ingestion | |
Vomiting within a few minutes and up to 2 hours after eating, usually accompanied by skin rashes or respiratory symptoms | Food allergy |
Subacute clinical features with diarrhoea | Bowel disease due to food intolerance |
After introducing lactose | Galactosemia |
After introducing fructose/sucrose | Hereditary fructose intolerance |
Indigestion with vomitings | Achalasia |
Source: Shields & Lightdale, 2018
Vomiting is nonspecific in childhood and may be caused by a variety of conditions. Once we have evaluated the degree to which the general state of health has been affected, the priority is to rule out the most serious causes of vomiting in children: surgical abdomen, severe non-surgical abdominal conditions, intracranial infection, intracranial hypertension, sepsis, and severe metabolic disorders (Hyams et al., 2016) , See Table 3. Clinical guidance 2.
EXAMINATION | CLINICAL GUIDANCE |
---|---|
HISTORY | |
Marked abdominal distension, visible intestinal loops, bilious emesis, absence of bowel movements or borborygmi, flatulence, foul-smelling stools | Bowel obstruction |
Hepatosplenomegaly, jaundice | |
Ataxia, dizziness, nystagmus | Vestibular condition or acute cerebellar ataxia |
Papilloedema | Increased ICP |
Ambiguous genitalia | Congenital adrenal hyperplasia or adrenal insufficiency |
Strange smell (bad breath) | Metabolic problem |
Parotid inflammation | Bulimia |
Source: Hyams et al., 2016
The evidence indicates some tests that are easy to interpret and do not require complex resources, which can guide the diagnostic-therapeutic approach, and which are included in the following table. Table 4. Usefulness of laboratory tests
Beyond the aetiological approach, which is of paramount importance, symptom management often focuses on treatment in the community care setting.
Without evidence of severity, improvement in clinical features is achieved by allowing the bowel to rest and maintaining an adequate level of hydration. The basic pillars of the management of AGE are oral rehydration and early feeding. In the case of infants, early feeding should be maintained and, in the rest of children, the intake of hydroelectrolytes should be ensured in accordance with the losses and without forcing early feeding (Shields & Lightdale, 2018)
Together with this, the use of antiemetic medication encourages the positive progression of the most acute symptoms. There are numerous drugs and therapeutic regimens depending on age, the characteristics of the drug, and the clinical features being addressed (Hyams et al., 2016), (Phillips et al., 2010) ,.
Table 5. Most frequently used medications , summarises the most frequently used medications with the greatest evidence for safe use in clinical settings, including their complications or recommendations for the paediatric setting (Frelich et al., 2018), (Tomasik, Ziółkowska, Kołodziej, & Szajewska, 2016)
MEDICATION | DOSE | GROUP / RECEPTOR | NOTES |
---|---|---|---|
Ondansentron | 0.3-0.4 mg/kg per dose every 4-6 h | Serotonin antagonist / 5-HT3 | May cause diarrhoea |
Granisetron | 40 μg/kg/dose every 12 h | Serotonin antagonist / 5-HT3 | |
Ginger | 250 mg every 8 h | Serotonin antagonist | The mechanism of action of ginger is not completely understood |
Amitriptyline | 0.25 mg/kg per day (max. 1 mg/kg per day) | Antidepressant / Serotonin | Increased risk of cardiac arrhythmia |
Erythromycin | 0.5 mg/kg per dose every 6 h | Prokinetic | Can increase risk of pyloric stenosis in infants |
Cyproheptadine | 0.25-0.5 mg/kg per day | Antihistamine / H1 | Stimulates appetite |
Diphenhydramine | 5 mg/kg per day (divided into 3-4 doses) | Antihistamine / H1, D2 | |
Promethazine | 5-10 mg/kg every 4-6 h (≥ 40 kg) | Dopamine antagonist / D2 | Contraindicated in children < 2 y old due to respiratory depression |
Metoclopramide | 0.1-0.2 mg/kg per dose every 4-6 h | Dopamine antagonist / D2 | Increased risk of tardive dyskinesia (extrapyramidal condition) |
Aprepitant |
Children 6-30 kg: 3 mg/kg on day 1, then 2 mg/kg on days 2 and 3. Children >30Kg: 125 mg on day 1, then 80 mg on days 2 and 3. |
Neurokinin (central) / NK1 | Indicated for chemotherapy-induced nausea. Causes fatigue, dizziness. Not for long-term use |
Source: Shields & Lightdale, 2018
This publication has been possible to the cooperation program Interreg VA España-Portugal POCTEP - RISCAR 2014-2020.
The Journal of Childhood and Health (Revista Infancia y Salud - RINSAD), ISSN: 2695-2785, arises from the collaboration between the administrations of Portugal, Galicia, Castilla y León, Extremadura, and Andalusia, within the Interreg Spain-Portugal RISCAR project, and aims to disseminate scientific articles on children’s health, providing researchers and professionals with a scientific base from which to learn about the latest advances in their respective fields.
The RISCAR project is co-financed by the European Regional Development Fund (ERDF) through the Interreg Program V-A Spain-Portugal (POCTEP) 2014-2020, with a total budget of € 649.699.
RINSAD is the result of the Interreg Spain - Portugal RISCAR project in collaboration with the University of Cádiz and the Nursing and Physiotherapy Department of the University of Cádiz , Cádiz, Spain.
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